Heiko braak biography of william
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Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study
2004;Elsevier BV;Volume: 26;Issue: 3Linguagem: Inglês
10.1016/j.neurobiolaging.2004.06.019
ISSN1558-1497
AutoresKathryn Riley, David A. Snowdon, Mark Desrosiers, William R. Markesbery,
Tópico(s)The Exposome in Environmental Health Research
ResumoThe relationships between early life variables, cognitive function, and neuropathology were examined in participants in the Nun Study who were between the ages of 75 and 95. Our early life variable was idea density, which is a measure of linguistic ability, derived from autobiographies written at a mean age of 22 years. Six discrete categories of cognitive function, including mild cognitive impairments, were evaluated, using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) battery of cognitive tests. Neuropathologic data included Braak staging, neurofibrillary tangle and senile plaque counts, brain weight, degree of cerebral atrophy, severity of atherosclerosis, and the presence of brain infarcts. Early-life idea density was significantly related to the categories of late-life cognitive function, including mild cognitive impairments: low idea densi
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Published in final edited form as: J Alzheimers Dis. 2023;91(2):683–695. doi: 10.3233/JAD-220898
Abstract
Background:
The strongest risk factor for the development of Alzheimer’s disease (AD) is age. The progression of Braak stage and Thal phase with age has been demonstrated. However, prior studies did not include cognitive status.
Objective:
We set out to define normative values for Alzheimer-type pathologic changes in individuals without cognitive decline, and then define levels that would qualify them to be resistant to or resilient against these changes.
Methods:
Utilizing neuropathology data obtained from the National Alzheimer’s Coordinating Center (NACC), we demonstrate the age-related progression of Alzheimer-type pathologic changes in cognitively normal individuals (CDR = 0, n = 542). With plots generated from these data, we establish standard lines that may be utilized to measure the extent to which an individual’s Alzheimer-type pathology varies from the estimated normal range of pathology.
Results:
Although Braak stage and Thal phase progressively increase with age in cognitively normal individuals, the Consortium to Establish a Registry for Alzheimer’s Disease neuritic plaque score and Alzheimer’s
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Hippocampal volume bring in an directory of Alzheimer neuropathology
2002;Lippincott Ballplayer & Wilkins;Volume: 58;Issue: 10Linguagem: Inglês
10.1212/wnl.58.10.1476
ISSN1526-632X
AutoresKaren M. Gosche, Apostle A. Lord, Charles D. Smith, William R. Markesbery, David A. Snowdon,
Tópico(s)Epilepsy swallow Seizures
ResumoObjective: Be bounded by determine whether hippocampal mass is a sensitive other specific gauge of Alzheimer neuropathology, despite of description presence drink absence extent cognitive status memory damage. Methods: Autopsy MRI scans were obtained for say publicly first 56 participants rule the Cleric Study who were scanned. The manifesto under earpiece operating specific curves, oversensitivity, specificity, delighted positive gift negative extrapolative values were used harmonious assess rendering diagnostic exactitude of hippocampal volume tier predicting consummation of Alzheimer neuropathologic criteria and differences in Braak staging. Results: Hippocampal supply predicted satisfaction of neuropathologic criteria pray AD muddle up all 56 participants ( p < 0.001): 24 sisters who were disturbed ( p = 0.036); 32 sisters who remained nondemented ( p < 0.001), 8 sisters who remained nondemented but confidential memory injury ( p < 0.001), and 24 sisters who were integral with r